Tumeurs stromales gastro-intestinales

Summary

This book is based on a retrospective survey of members of the AFC (French Surgery Association), which compiles the notes of almost 1 500 files of patients undergoing surgery in the last 13 years.
The main objective was to present an overview of surgical and oncological practices and treatments. This is one of the largest gastrointestinal tumour series to date. The conclusions reached after the analysis of the data are extremely valuable from a scientific standpoint.

Table of content

A reminder of the basics

• Epidemiology
• Pathology
• GIST genetics and molecular biology

Paraclinical examinations

• Contribution of morphological and metabolic examinations to the initial workup and the evaluation of response to treatment
• Role played by endoscopic examinations in the initial workup, treatment and monitoring of unoperated GISTs (including EE)
• Utility of biopsy and biopsy procedures

Treatment methods

• Surgical treatment
• GIST surgery quality criteria and current role of laparoscopy
• Intraoperative surgical strategy depending on the organ
• Esophagus and extra-gastrointestinal locations
• Stomach, duodenum
• Small bowel, colon, rectum
• Role of surgery (and other local treatments) for metastatic GISTs (primary tumour surgery, surgery for metastases, surgery for clones)
• Post-surgery monitoring methods and importance of monitoring
• Medical treatment
• Mode of action of the different molecules
• Neoadjuvant and adjuvant treatment
• Treatment for metastatic disease and recurrence
• Conclusion